MD Anderson is known for providing cancer patients with exceptional care, which includes early access to innovative new treatments through clinical trials. The Institute for Applied Cancer Science (IACS) is a new hybrid model that uniquely combines the drug discovery capabilities of the biopharmaceutical industry and the extensive knowledge of biology found in academia with the expertise of MD Anderson’s top clinicians. IACS has the singular goal of rapidly developing novel, effective and safe therapeutics that improve patient health. IACS executes programs with the highest probability of clinical success in a rigorous, goal-oriented, data-driven manner. We are seeking a highly motivated and team-oriented individual to join our in vitro Pharmacology group to support our fast-paced drug discovery programs.
The Institute Research Scientist participates in cross-functional research to identify and validate novel oncology targets, and translate these finding into novel oncology therapeutic agents to benefit patients. He/she will provide in vitro Pharmacology leadership on small molecule drug discovery project teams and use their biochemistry/enzymology skills to elucidate the mechanism of action of new chemical matter.
1. Fully characterize mechanism of action and kinetics of lead molecules using biochemical and biophysical techniques.
2. Responsible for the development, optimization, validation, implementation, and execution of biochemical and biophysical assays for medium and high-throughput screening to support target validation and lead optimization in small molecule drug discovery projects.
3. Implement novel in vitro screening strategies; plan and execute screening and counter screening funnels for drug discovery programs.
4. Monitor assay quality and troubleshoot issues with assay performance.
5. Contribute to project teams through lab-based activities.
6. Interact closely with other biologists and medicinal chemists on discovery-based project teams.
7. Transfer assays to collaborators as appropriate.
8. Work closely with research teams to identify and recommend opportunities leading to scientific discovery and clinical therapeutic drug development.
9. Interact across cross-functional groups.
10. Employ safe lab practices
11. Maintain research records and laboratory notes.
12. Apply and develop cutting edge basic science tools and methodologies to enable advancement of Institute projects through leadership and experimental activities. Analyze data generated by various studies and leverage results for the design of future studies.
13. Apply state of the art basic science skills to prepare complex strategies.
14. Adapt to new technologies and find solutions to related program studies.
Required: Bachelor’s degree in Biology, Biochemistry, molecular biology, cell biology, enzymology, pharmacology, chemistry or related field.
Preferred: PhD in biochemistry, biomedical science, pharmacology, or related field or a Medical degree.
Required: Ten years of relevant research laboratory experience. With Master’s degree, eight years of required experience and with PhD, two years of required experience.
Preferred: At least four years of relevant experience within the pharmaceutical industry.
Ideal Candidate will possess the following:
• A demonstrated track record in the development and implementation of biochemical assays for compound screening using a variety of detection formats (fluorescence, radiometric, etc.)
• Mechanism of action experience with multiple enzyme families
• Cell-based assay experience in a drug discovery setting
• Experience in target-based drug discovery
• Experience running automated liquid handling instrumentation
• Strong data analysis skills, ability to interpret results and contribute to the design of follow-up experiments
• Ability to effectively present results and conclusions
• High attention to detail
• Ability to work well under pressure and meet critical timelines
• Collaborative attitude and the ability to work effectively on multi-disciplinary project teams
• Industry experience
It is the policy of The University of Texas MD Anderson Cancer Center to provide equal employment opportunity without regard to race, color, religion, age, national origin, sex, gender, sexual orientation, gender identity/expression, disability, protected veteran status, genetic information, or any other basis protected by institutional policy or by federal, state or local laws unless such distinction is required by law. http://www.mdanderson.org/about-us/legal-and-policy/legal-statements/eeo-affirmative-action.html
Source: Nature Jobs