Chromosome Segregation

This is a full-time, fixed term position for four years on Crick Terms & Conditions of Employment.
Salary between £33,500 – £36,600 per annum, subject to skills and experience.

Context

The Francis Crick Institute is a new research institute with a distinct vision of how biomedical research is conducted. It is one of the most significant projects in UK biomedical science for a generation. The institute’s laboratories have an international reputation for cutting-edge research into basic biology and are committed to training the next generation of research scientists. The four-year Postdoctoral Training programme is part of this commitment and nearly half of the Postdoctoral Fellows leave to set up their own research groups. Postdocs also benefit from living and working in one of the world’s greatest scientific, cultural and cosmopolitan capital cities.

The Francis Crick Institute (the Crick) is a partnership between the Medical Research Council (MRC), Cancer Research UK (CRUK), the Wellcome Trust, University College London (UCL), Imperial College London and King’s College London. It is a registered charity whose purpose is to conduct biomedical research into all aspects of human health and disease.

The institute will be a world-leading centre of biomedical research and innovation. It will promote connections between researchers and disciplines and between academic institutions, healthcare organisations and businesses. Dedicated to research excellence, the institute will have the scale, vision and expertise to tackle the most challenging scientific questions underpinning health and disease. It will be world-class with a strong national role — training scientists and developing ideas for public good. On 1 April 2015, staff from the London Research Institute (CRUK) and National Institute for Medical Research (MRC) transferred to the Crick to form a fully functional research institute on four sites. In 2016, the Crick will move to a single new, purpose built research centre in St. Pancras which will house some 1,500 staff.

We seek a talented and motivated postdoc to analyse biochemical and functional aspects of the chromosomal cohesin complex to join Dr Frank Uhlmann’s laboratory.

Organisation

Dr Uhlmann’s laboratory focuses on the mechanisms of chromosome segregation during cell division. Details of research projects currently being undertaken can be seen at: http://www.crick.ac.uk/research/a-z-researchers/researchers-t-u/frank-uhlmann/Research
Techniques used in the laboratory include state of the art yeast genetics and genomics as well as biochemical approaches.

Objectives

The research aims to understand the mechanism of sister chromatid cohesion establishment by the chromosomal cohesin complex at the budding yeast DNA replication fork and will contribute to the research funded by an ERC grant. In this project, some of the specific aims could include but are not limited to:
• Purification and biochemical analysis of the yeast cohesin complex
• Analysis of its DNA binding
• Analysis of its behaviour during the establishment of sister chromatid cohesion

Person Specification

The post holder should embody and demonstrate our core Crick values: Bold, Imaginative, Open, Dynamic and Collegial, in addition to the following:

Essential

• PhD in the field of Biophysics or Biochemistry
• Good knowledge and experience in the biochemical analysis of chromosomal proteins in an in vitro setting
• Experience with yeast genetics and molecular biology
• Track record of writing papers as evidenced by publications or submitted manuscripts in international journals
• Evidence of data presentation at scientific meetings
• Experience of experimental design
• Ability to work independently and also capable of interacting within a group

Desirable

• Experience in research with model biological system
• Experience in the field of biochemistry and protein purification
• Experience in yeast genetics

All Postdoctoral Training Fellows are expected to lead on their own projects and contribute to other projects on a collaborative basis, both within the laboratory and with collaborators. The ability to work as part of a team is essential.

If you are interested in applying for this role please apply through our online system:

http://jobs.crick.ac.uk

For any questions relating to this role, please contact jobs@crick.ac.uk…