Postdoctoral Research Assistant (Uncovering PAWS1 function and regulation in cells and cancer)


Reference Number: SLSC0116
Job Title: Postdoctoral Research Assistant (Uncovering PAWS1 function and regulation in cells and cancer)
School: Life Sciences
Unit: MRC Protein Phosphorylation and Ubiquitylation Unit
Grade: Grade 7 (£30,738-£37,768)
Job Category: Research
Closing Date: 30 June 2016

Applications are invited for a postdoctoral position to work with Dr. Gopal Sapkota to investigate the molecular function and regulation of PAWS1/FAM83G in cells and cancer. Following the discovery of PAWS1 (Protein Associated With Smad1) as a player in the BMP pathway in the lab, we have established key roles for PAWS1 in transcription, cell migration and cancer. This project aims to uncover the molecular mechanisms of PAWS1 function in cells and understand how PAWS1 itself is regulated. The project will exploit state-of-the-art technologies including CRISPR/CAS9 genome-editing, mass spectrometry, fluorescence microscopy as well as other molecular, cellular and biochemical techniques.

MRC Protein Phosphorylation and Ubiquitylation Unit (PPU):

The successful applicant will have the opportunity to work in an exciting and collaborative research environment, equipped to the highest international standards. Major aims of the MRCPPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease; to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation; and to generate reagents and improve technologies. Another key remit of the MRCPPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research. The MRCPPU is in a beautiful location overlooking the estuary of the River Tay and embedded within the School of Life Sciences at the University of Dundee, which is one of the premier Life Sciences research Centres in the world.

Candidate requirements:

• A recent PhD, with an outstanding academic track record and at least one first-authored research publication in an internationally recognized peer-reviewed journal.
• Strong background in biochemistry, molecular biology, cellular biology, signal transduction and transcriptional studies.
• Strong background in cancer would be desirable.
• Capable of working in a team, but able to plan and work independently.
• Excellent communication skills and knowledge of the English language.
• Able to start on or soon after June 1st 2016.

The postdoctoral position will be for 3 years.

How to apply:

To apply on-line please visit: If you are unable to apply on-line please contact Human Resources on (01382) 386209 (answering machine) for an application pack. Please quote reference number SLSC0116.

The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community.

The University of Dundee is a Scottish Registered Charity, No. SC015096.

Don’t forget to mention Naturejobs when applying.

Source: Nature Jobs

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