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Postdoctoral position in mammalian epigenetics

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A post-doctoral position funded for up to 3 years is available in our group. We study epigenetic regulators in mammalian cells; more precisely we are interested in the modifications of DNA (methylation, hydroxymethylation, …), the proteins that recognize epigenetically modified DNA, and the functional consequences of these phenomena.

Our group is part of a highly successful department devoted to Epigenetics and Cell Fate. The workplace is friendly and international and the working language is English. We are located in a recent research facility in a vibrant area of Paris. The campus houses a cluster of Life Sciences institutes and provides access to state-of-the-art facilities including Genomics, Proteomics, and Imaging. Visit our website http://parisepigenetics.com/ for more details on the lab and our research interests. Informal enquiries by email to PA Defossez are also welcome if you want to find out more.

The funded project investigates the dynamics of DNA remethylation in mammalian cells during DNA replication and DNA repair. More specifically, it focuses on UHRF1, an essential protein that promotes epigenetic memory. We have identified a new mechanism by which UHRF1 is recruited to DNA. We will investigate the consequences of this mechanism, continue to decipher the function of UHRF1 via new interactors we have identified, and develop original tools to characterize DNA remethylation dynamics. The methods used include mouse ES cell culture, CRISPR mutagenesis, whole-genome methylation analyses, proteomics, and live-cell imaging.

The project will give the applicant significant input in determining its direction, and will benefit from our well-established networks of collaborations, in France, Europe, and Japan.

A doctoral degree, experience in cellular and molecular biology, and proficiency in English, are required. Candidates must be highly motivated, interactive, and have a successful track record.

Applications will be considered until the position is filled. To apply, please send your CV, a motivation letter, and the names of two references to:

Pierre-Antoine.Defossez@univ-paris-diderot.fr

Don’t forget to mention Naturejobs when applying.

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Source: Nature Jobs

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