Meeting report from the Euroscicon event: 14^th November 2012, Stevenage, UK

Chair: Professor Gary J Lye, PhD, CEng, CSci, FIChemE, Director Industrial Doctoral TrainingCentre, Deputy Head of Department, The Advanced Centre for Biochemical Engineering, Department of BiochemicalEngineering, University College London, UK

Author: Dr Yuen Ling Ng, University of Nottingham, Department of Chemical & Environmental Engineering

Editor: Dr Astrid Englezou

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Miniaturisation is the small-scale cultivation of biological cells. Miniature bioreactors are used for the purposes of screening for positive clones, optimisation of culture conditions, formulation and bioprocess development. Miniaturisation and automation enable high throughput parallel process optimisation and development at low costs and development time. The Annual Miniaturisation Event has seen many successes in the development of the technologies that have found their ways into various industrial applications. The two main bioreactor designs featured in the 2012 meeting were the microwell plates and the miniature stirred bioreactor. The bioreactors were presented with many advanced features and variations, and were showcased in the meeting for applications in microbial, mammalian and stem cell cultivations, and in tissue engineering.
CONTENTS
Abstract

Shaken or stirred – miniature bioreactors for rapid process development

Miniaturised bioreactors – the future for small scale process

Streamlining cell line evaluation using micro bioreactor systems

Use of micro scale mammalian cell culture in process development

Functionalising cell signalling in microscale production of differentiated cells and tissue engineering

Characterisation of an automated micro bioreactor with CHO cultures: process control, clone ranking, process optimisation and DoE.

Small scale fed batch cultivation of Escherichia coli: carbon limited growth in microtiter plates

High throughput screening & analytics for rapid process development

Profiling the CHO host cell proteome and development of alternative downstream processing of recombinant proteins

Conclusion.

References:

Abstracts

Shaken or stirred – Miniature bioreactors for rapid process development

Streamlining cell line evaluation using micro bioreactor systems

Characterisation of an automated micro bioreactor with CHO cultures: process control, clone ranking, process optimisation and DoE.

Small scale fed batch cultivation of Escherichia coli: carbon limited growth in microtiter plates 7

Biographies:

Gary Lye.

Barney Zoro.

POSTERS.

Small scale fed batch cultivation of Escherichia coli: carbon limited growth in microtiter plates

Streamlining cell line evaluation using micro bioreactor systems

Cell-To-Cell Adhesion And Adhesion To Extracellular Matrix Molecules In Directing Stem Cell Proliferation And Differentiation.

Profiling the CHO host cell proteome and development of alternative downstream processing of recombinant proteins

Figure 1  Professor Gary J Lye (Chair) and speakers

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• Format: Kindle Edition
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• Print Length: 16 pages
• Publisher: Honnao (19 Jun 2013)
• Sold by: Amazon Media EU S.à r.l.
• Language: English
• ASIN: B00DI92ZEE