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Manager, Senior Scientific Investigator, Transduction Vector Production

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WD25864 Manager/Senior Scientific Investigator Transduction Vector Production

Basic qualifications:
• PhD degree in Immunology/ Molecular Biology / Vectorology of postgraduate experience in biotech/ biopharma industry with an in depth practical understanding of lentiviral and plasmid DNA vectors for gene therapy/cell transduction.
• Scientific: Excellent molecular biology skills, with a strong understanding of vector engineering and construct design. Proven track record in the development of analytical methods for the characterization of Gene & Cell-based therapies.
• Teamwork: Demonstrated ability to lead effectively within a multi-disciplinary team and work with other internal and external business partners using influencing, communication and relationship building skills.
• Communication: Attention to detail and good communication and documentation skills will be expected, as will be a flexible commitment to adding value within the role. Demonstrated ability to effectively communicate your work and data to various audiences and senior takeholders in the form of presentations and written reports. Strong personal leadership and interpersonal skills to motivate mentor junior colleagues.
• Flexibility: Demonstrated ability to multitask and react and adapt to changing priorities and business direction.
Preferred qualifications:
• Experience in the analysis of protein protein interaction affinity and specificity by Biacore (or similar) and/or flow cytometry.
• Understanding of the identification of risks pre-clinically that might impact successful clinical development.
• Understanding of manufacturing processes for clinical lentiviral and or plasmid vectors.
Details:
GlaxoSmithKline is a world leading research-based pharmaceutical company that combines both individual talent and technical resources to create a platform for the delivery for strong growth in a rapidly changing healthcare market. Our mission is to improve the quality of human life by enabling people to do more, feel better and live longer.
Biopharm Innovation is the part of GSK‘s Biopharm R&D group focused on identifying and developing novel biopharmaceutical technologies to enable the creation of future medicines. These next generation technologies may come either from within GSK, or from the wider R&D community. Our current areas of focus include the development of bispecific antibodies, as well as aspects of cell and gene therapy.
The successful candidate will join Biopharm Innovation (initially in Protein Sciences) as part of the group specifically supporting cell and gene therapy applications. The group comprises molecular biologists, protein biochemists and bioanalysts, working as part of a closely integrated team with the lead discovery and biology groups supporting pre-clinical evaluation of gene therapeutics, and with the CMC team to ensure progression of developable assets.
You will have a strong molecular biology background and will be responsible for the for the design and optimisation of lentiviral and plasmid DNA constructs to support pre-clinical projects. You will lead a team working in close collaboration with key stakeholders in the unit and other analytical R&D groups to develop novel technologies and approaches to meet future transduction vector needs and associated analytical demands. This role will be pivotal in the smooth progression of leads from discovery processes to support pre-clinical evaluation, ensuring that the leads be smoothly progressed into development.
The ability to innovate and form productive interactions with scientists across GSK will be key skills for success in this role. You will be expected to maintain knowledge of current scientific literature relevant to the role. Your focus will be in the laboratory, with a desire to be involved in drug discovery projects and a willingness to develop and train others as required. You will be expected to perform data analysis, record keeping and reporting of results to corporate databases to agreed timelines, and give oral presentations of results at programme, group and departmental meetings.
Closing date for Applications: 19th of June 2015
Salary: Completive Salary +Benefits Package
Location: Stevenage (Hertfordshire)
When applying, please use the “Cover Letter” in the on-line application to outline how you meet the requirements of the role. The information that you have provided in your cover letter and CV will be used to assess your application.
Thank you for your interest in this opportunity …

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Source: Nature Jobs

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