Research Fellow in Structural Molecular Biology

University of Leeds

University of Leeds – School of Molecular & Cellular Biology

Location: Leeds – Main Campus
Faculty/Service: Faculty of Biological Sciences
Grade: Grade 7
Salary: £31,656 to £37,768 per annum
Please note that due to funding limitations an appointment will not be made above £31,656 p.a.
Contract Type: Fixed Term (until 31 January 2018, available immediately)

Project Title: ‘Integrated computational and synthetic tools to drive the discovery of orthosteric protein-protein interaction inhibitors’

You will join a major 5-year EPSRC-funded programme focused on developing, validating and then exploiting new tools for discovering inhibitors of Protein-protein interactions (PPIs). PPIs control almost all cellular processes relevant to health and disease, including many targets in oncology. Selective inhibition of individual PPIs would facilitate both a greater understanding of biological mechanisms and provide new opportunities for therapeutic intervention. Yet, PPI inhibitors represent a minute fraction of current small molecule drugs, largely because of specific challenges associated with development of inhibitors for these targets. This position will use structural biology and biophysics to assess the application of our methods for preparing diverse three-dimensional scaffolds in the discovery of small molecule inhibitors of multiple PPIs. The programme is highly interdisciplinary, and will involve collaboration with the University of Bristol and a range of drug discovery organisations. The position will thus also provide many opportunities for personal development, as well as the possibility of research secondments at Bristol and/or our drug discovery partners.

You will have a PhD (or be close to completion) in Chemical Biology, Structural Biology or Biochemistry and you will have demonstrable ability to successfully apply extensive knowledge of both modern Molecular Biology and Protein Purification. Expertise in protein crystallography and/or biomolecular NMR spectroscopy is desirable.

Informal enquiries may be made to Dr Thomas Edwards email, tel +44 (0)113 343 3031 or Professor Andy Wilson, email, tel +44 (0)113 343 1409

Click here for further information about working at the University of Leeds

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