02 April 2014
www.regonline.co.uk/geneobesity2014
Cineworld: The O2, London, SE10 0DX, UK
It has become clear that there are large individual differences in the responsiveness to well-defined energy balance manipulations to control obesity. Overfeeding as well as negative energy balance protocols indicate that the response to standardized experimental treatments is strongly influenced by genetic background. However, testing gene-environment interaction is a relatively new field. This event will discuss identifying the genetic and environmental risk factors (lifestyle and diet) for obesity and the evidence for gene-environment interaction will be examined. This event will be an idea setting to find out what is new in the field, to network and to meet the experts.
Meeting Chair: Dr Clare Llewellyn, Lecturer in Behavioural Obesity Research, University College London and King’s College London, UK
This event is part of the 2014 Obesity Summit - www.obesitysummit2014.comand has CPD accreditation
Who Should Attend
Biotech and Pharma Industry: CEOs, Chief Scientists, Group Heads, Senior and Junior Scientists, Research Managers
Academic and Research Institutes: Group and Lab Heads, Postdoctoral Scientists and Research Students
Clinical specialists: Clinicians and dietitians specialising in obesity
The Deadline for abstract submissions for oral presentation is Feb 10th 2014
Abstracts for poster presentation only can be submitted up to two weeks before the event
.
You can download the instructions for authors at
www.euroscicon.com/AbstractsForOralAndPosterPresentation.pdf
Talk times include 5 – 10 minutes for questions
9:00 – 9:45 Registration
9:45 – 10:00 Introduction by the Chair: Dr Clare Llewellyn, Lecturer in Behavioural Obesity Research, University College London and King’s College London, UK
10:00 – 10:30 Talk to be confirmed
Dr Teresa Arora , Sleep and Metabolic Research Scientist, University of Birmingham, UK
10:30 – 11:00 Talk to be confirmed
Professor Gertjan Van Dijk, Center for Behavior and Neurosciences, University of Groningen, The Netherlands
11:00 – 11:30 Speakers’ photo then mid-morning break and poster exhibition and trade sho
11:30 – 12:00 Talk to be confirmed
Dr L. Joseph Su, National Institutes of Health, National Cancer Institute, USA
12:00 – 12:30 ORAL PRESENTATIONS
12:30 – 13:30 Lunch, poster exhibition and trade show
13:30 – 14:30 Discussion Panel
14: 30 – 15:00 Different expression of certain adipokines in subcutaneous and visceral tissues between obese and non-obese subjects and their correlations with clinical parameters and periphera metabolic factors.
Dr Chantacha Sitticharoon, Department of Physilogy, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand
NPY and Y5R mRNA expressions were higher in obese than in non-obese humans in both subcutaneous and visceral fat. In visceral fat, Y1R mRNA was greater while Y2R was lower in obese than in non-obese subjects. In visceral fat, Y1R mRNA was positively correlated with body weight, BMI, waist and hip circumferences, insulin, and HOMA-IR and Y5R mRNA was positively correlated with body weight, BMI, hip circumference, and serum leptin. Subcutaneous adiponectin mRNA was higher in non-obese group compared to obese group. Subcutaneous mRNA expressions of adiponectin, visfatin, and omentin were positively correlated with QUICKI but negatively correlated with BMI.
15:00 – 15:30 Afternoon Tea, last poster session and trade show
15:30 – 16:00 Talk to be confirmed
Dr Irene Maeve Rea, Senior Lecturer and Consultant Physician Geriatric Medicine, Queens University Belfast, Northern Ireland
16:00 – 16:30 Genetic and Environmental Determinants of Comorbid Obesity in Major Psychiatric Disorders
Dr Margarita Rivera, BRC Senior Postdoctoral Researcher, MRC SGDP Centre, Institute of Psychiatry, King’s College London, UK
People with major psychiatric disorders (major depressive disorder, bipolar disorder, schizophrenia), particularly with mood disorders, have higher prevalence of comorbid obesity-related diseases, such as type 2 diabetes, metabolic syndrome and cardiovascular disease. The relationship between mental and physical disorders is complex and not clearly understood. Although it is well reported that these related diseases have a high impact in the lifespan and mortality of people with psychiatric disorders. Recent studies support the hypothesis that there may be shared aetiological factors, including genetic and environmental risk factors, between psychiatric disorders and obesity-related diseases. The talk will highlight the evidence of genetic and environmental risk factors implicated in the comorbidity of obesity-related diseases in major psychiatric disorders.
16:30 - 17:00 Obesity, leptin and respiratory control
Dr Mirian Bassi, Post-Doctoral,School of Dentistry, São Paulo State University (UNESP), Araraquara, Sao Paulo-Brazil
Evidence suggests that, in addition to regulate energy homeostasis and sympathetic activity, leptin also contributes to the CNS control of breathing. Obese transgenic leptin deficient (ob/ob) mice have an impaired respiratory response to hypercapnia that can be reverted by leptin treatment. Although the cellular basis for leptin effects on respiratory control is unknown, data from our studies have shown thatmelanocortin 3/4 receptors (MC3/4R), a system that play a pivotal role in mediated metabolic and cardiovascular actions of leptin. also can mediated leptin effects on ventilation. In addition, we demonstrated that leptin may act in an important nucleus located in the ventral chemorespiratory surface of medulla called retrotrapezoid (RTN) to induces these respiratory alterations.
17:00 Chairman’s summing up
About the Chair
Clare Llewellyn had an initial career working on the commercial side of the pharmaceutical industry, before she retrained as a psychologist, completing an MSc in Health Psychology, then a PhD focusing on genetic influences on appetite and growth, both at University College London (UCL). She is currently a Lecturer in Behavioural Obesity Research at the Health Behavioural Research Centre, UCL. The main focus of her work is to understand why some individuals gain weight, but others remain effortlessly lean, in response to the current ‘obesogenic’ environment. Given that body weight is highly heritable, researchers have been tasked with marrying up the seeming paradox of both genetic and environmental determination of weight. The hypothesis that Clare has been developing is that ‘obesity genes’ influence weight through their effects on appetite, thereby providing a platform for gene-environment interaction – individuals who inherit a more avid appetite are susceptible to overeating in an environment with an abundant food supply, and at risk of excessive weight gain.
About the Speakers
Chantacha Sitticharoon graduated from Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand in 2001 with honours. She completed her PhD degree in Physiology from Faculty of Medicine, Nursing and Health Sciences, Monash University Australia in 2009. Her PhD thesis was about expressions of appetite regulating peptides in sheep hypothalamus in various conditions. Now, She has been working as an instructor at Department of Physilogy, Faculty of Medicine Siriraj Hospital, Mahidol University, Thailand since 2001. Her reseach interests include obesity, appetite regulation, and regulation of reproduction, especially factors involved in early onset of puberty.
Margarita Rivera is a BRC Senior Postdoctoral Researcher at the MRC Social, Genetic and Developmental Psychiatry Centre, Institute of Psychiatry. Her work focuses on investigating the genetic relationship between major psychiatric disorders, mainly depression and bipolar disorder, and obesity-related diseases (i.e. type 2 diabetes, metabolic syndrome, cardiovascular disorders, etc). The goal of her research is to get a better understanding of the molecular genetic basis of comorbidity between psychiatric disorders and obesity-related diseases, both of which have major public health, clinical, economic, personal and social implications worldwide.
Mirian Bassi: Physiotherapist, Specialist in Pulmonary Rehabilitation (2002); Master degree (2004) and Ph.D. (2008) in Physiological Sciences at Medical School of São Paulo University, Ribeirão Preto- Brazil; Post-doctoral training in cardiovascular physiology at Guyton Research Center, University ofMississippi Medical Center, USA (2009) in collaboration with Dr. John E. Hall; Visiting Research at Department of Physiology and Neurobiology, University of Connecticut, USA (2012) in collaboration with Dr. Daniel Mulkey, studding the central role of leptin on neuronal activity of respiratory neurons (electrophysiology). Currentily is is post-doc fellow at the Department of Physiology and Pathology, School of Dentistry - São Paulo State University, Brazil studing participation of leptin on cardiorespiratory control mechanisms.
Post expires at 10:17am on Wednesday April 2nd, 2014
Tags: adiponectin, biomarker, biomarkers, Blood, BMI, breathing control, cell defence, chemoreception, depression, environment, FTO gene, gene expression, genetics, homeostasis, leptin, melanocortin receptors., NPY, NPY receptors, obesity, Obesity; genes; environment; gene-environment interaction; obesogenic, omentin, proteomics, psychiatric disorders, visfatin
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