26 February 2014
www.regonline.co.uk/AgeMed2014
Cineworld: The O2, London, SE10 0DX, UK
The last three decades have shown us how plastic the ageing process can be. It is becoming apparent that, with increased knowledge, more and more of the negative consequences of ageing can now be tackled, postponed or avoided. This meeting aims to review the most up to date science about how we can positively modulate ageing and the implementation of such results to human ageing.
This event is part of the 2014 Ageing Summit
This event has CPD accreditation
Who Should Attend
Biotech and Pharma Industry: CEOs, Chief Scientists, Group Heads, Senior and Junior Scientists, Research
ManagersAcademic and Research Institutes: Group and Lab Heads, Postdoctoral Scientists and Research Students
The Deadline for abstract submissions for oral presentation is November 10th 2013
Abstracts for poster presentation only can be submitted up to two weeks before the event
You can download the instructions for authors at
www.euroscicon.com/AbstractsForOralAndPosterPresentation.pdf
Meeting Chair: Dr Nadège Minois, Biomedical Sciences Research Complex, University of St Andrews, Scotland
Talk times include 5 – 10 minutes for questions
9:00 – 9:45 Registration
9:45 – 10:00 Introduction by the Chair: Dr Nadège Minois, Biomedical Sciences Research Complex, University of St Andrews, Scotland
10:00 – 10:30 The effects and mechanisms of action of spermidine on ageing
Dr Nadège Minois, Biomedical Sciences Research Complex, University of St Andrews, Scotland
Spermidine is a natural polyamine with important functions such as DNA stability, cell survival, growth and proliferation. Its level decreases with age and we have shown that supplementing spermidine in food or water increases life span in several model organisms and human cells in culture. It also increases stress resistance and delays age-related oxidative damage and locomotor activity decline. The main mechanisms of action of spermidine are general hypoacetylation and autophagy induction. The talk will review the findings on the role of spermidine on ageing and discuss the potential outcome for human ageing of spermidine supplementation.
10:30 – 11:00 Stem cell ageing and chemical intervention
Dr Ilaria Bellantuono, Reader in Stem Cell and Skeletal Ageing, The University of Sheffield
Stem cells are responsible for tissue repair and maintenance and evidence suggest that changes in stem cells with age contribute to the decline in tissue function. The ability to intervene and increase even modestly the number of stem cells, delaying tissue dysfunction may have great impact in areas of degenerative diseases. Indeed limited rejuvenation of stem cells has been shown to rescue tissue function. Small molecules are attractive to amplify the endogenous stem cell pool, preserve it from ageing and direct its differentiation by targeting specific signaling pathways. Here we will present data showing how mesenchymal stem cell ageing can be delayed using chemical interventions
11:00 – 11:30 Speakers’ photo then mid-morning break and poster exhibition and trade show
Please try to visit all the exhibition stands during your day at this event. Not only do our sponsors enable Euroscicon to keep the registration fees competitive, but they are also here specifically to talk to you
11:30 – 12:00 Use of Kinetic Isotope Effect to Mitigate Age-related Oxidative Stress Diseases
Dr Mikhail Shchepinov, CSO, Retrotope, Inc
Key oxidation prone positions within biomolecules can be reinforced with deuterium to make them more resistant to oxidative stress courtesy of the isotope effect. Use of this approach in mitigation of age-related diseases will be discussed.
12:00 – 12:30 ORAL PRESENTATIONS
12:30 – 13:30 Lunch, poster exhibition and trade show
Please try to visit all the exhibition stands during your day at this event. Not only do our sponsors enable Euroscicon to keep the registration fees competitive, but they are also here specifically to talk to you
13:30 – 14:30 Discussion Panel
14: 30 – 15:00 Talk to be confirmed
15:00 – 15:30 Afternoon Tea, last poster session and trade show
15:30 – 16:00 Gut microbes as drug targets to slow ageing
Dr David Weinkove, Lecturer, School of Biological and Biomedical Sciences, Durham University
We have coevolved with an amazing diversity of microbes. Evolution theories of ageing predict that gut microbes that aid nutrition might also increase ageing. Our research with the nematode Caenorhabditis elegans suggests that microbes limit lifespan through specific metabolic pathways. Targeting microbes with antibiotics disrupts microbiome diversity and increases susceptibility to harmful infection. However, we show the production of excess folate by the bacteria Escherichia coli can be inhibited without slowing the growth of either the microbe or animal. We propose that drugs that target specific pathways of microbial metabolism without killing cells are viable prospects for anti-ageing medicines.
16:00 – 16:30 Talk title to be confirmed
16:30 - 17:00 Chairman’s summing up
About the Speakers
Nadège Minois has been studying ageing since her PhD in Experimental Gerontology. She has worked at the University of Minnesota (USA), the Max Planck Institute for Demographic Research (Germany), the Research Institute of Molecular Pathology (Austria) and the University of St Andrews. She has tackled projects such as the effects of stress on ageing using the fly Drosophila melanogaster, the shape of mortality rates in the yeast Saccharomyces cerevisiae and a large-scale genetic screen to identify genes modulating life span in Drosophila. Her latest project is to study how spermidine, a natural polyamine, is involved in ageing using Drosophila.
Ilaria Bellantuonois Reader in Stem cell and Skeletal Ageing at the Mellanby Centre for Bone Research (MCBR), University of Sheffield and her research interests is in understanding what changes mesenchymal stem cells undergo with age and how these impact on bone loss. Central to her research programme is the identification of molecules which target stem cells in vivo to delay their ageing. Ilaria is Head of the Bone Analysis Laboratory at the MCBR, a facility which provides access to contemporary approaches for the analysis of bone. She heads the Shared Ageing Research Models (ShARM) funded by Wellcome Trust, which combines web-based information systems with a physical tissue bank of ageing mouse models and is the Director of training of the MRC- Arthritis Research UK Centre of Integrated research into Musculoskeletal Ageing (CIMA)
David Weinkove is a Lecturer in the School of Biological and Biomedical Sciences at Durham University. Throughout his career, his research has always involved using model organisms to address key questions in biology, combining genetic and biochemical techniques. Having discovered that an enzyme involved in cell signalling regulated growth in the fruitfly Drosophila during his PhD, he moved to the nematode C. elegans, training in the Netherlands, USA and UK. Using C. elegans he has made a number of contributions to ageing research and now works on how the microbe:animal interaction influences ageing, applying his work to mammals through collaborations.
Mikhail Shchepinov: MSc (Mendeleev Institute of Chemical Technology), PhD (Shemyakin-Ovchinnikov Bioorganic Chemistry Institute, Moscow). Worked in academia and industry (Oxford, UK; San Diego, USA) from 1995.
Post expires at 1:16pm on Wednesday February 26th, 2014
Tags: Ageing, Autophagy, DNA damage, folate, Health; Stem cells, isotope effect; ROS; age-related disease; essential polyunsaturated fatty acid; deuterium, Longevity, metabolic targets, microbes, Model Organisms, small molecules, Spermidine
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