Lilly is committed to “Making Science Personal” and delivering on the corporate strategy of “Improved Outcomes for Individual Patients”. A critical component of the organization that is required to execute this strategy is Lilly’s personalized medicine division: Tailored Therapeutics (TTx). TTx comprises both preclinical and clinical scientists specialized in understanding disease heterogeneity, development and validation of biomarker assays, and the conception and delivery of biomarker plans for clinical phase assets, with a special focus on building the science and the tools to identify the patients for which a given treatment will be safe and effective.
As an integral part of TTx Neuroscience, Lilly’s imaging group develops, evaluates, validates and applies imaging methods across all phases of drug discovery and development, providing tools for patient selection, quantitative metrics of target engagement, pharmacodynamic/functional effects and/or disease modification. This includes structural and functional MRI modalities as well as novel and established PET tracers. The imaging group works closely with cross-functional colleagues in genetics, biofluids, informatics and systems biology to advance disease understanding and address the needs of asset teams.
We are currently recruiting a Clinical Research Scientist to provide technical leadership focused on imaging biomarkers in support of the clinical portfolio, with particular emphasis on Alzheimer’s Disease and other neurodegenerative disorders. The successful candidate will be computationally adept, experienced in clinical imaging (both acquisition and analysis) and have a solid understanding of the current status and utility of biomarkers in neurodegeneration. He/she will be responsible for the design, conduct, and analysis of imaging biomarker studies and for scientific leadership in external collaborations. Moreover, he/she is expected to explore new opportunities to apply biomarker methods to drug development, and to help maintain and build a network of research partners.
•Work with cross-functionally with internal colleagues in the development and validation of imaging biomarkers to develop and test tailoring hypotheses and to support clinical drug development.
•Support Program Teams to develop biomarker strategies and incorporate imaging biomarkers into clinical development plans across the various therapeutic areas.
•Interact with external consultants, core labs and clinical investigators to plan, initiate, and conduct worldwide imaging biomarker trials.
•Work with the imaging group and with external collaborators/vendors to ensure robust data collection, imaging data oversight (quality control) and image analysis.
•Design and lead analyses of large, multimodal data sets aimed at understanding heterogeneity in patient populations.
•Perform specialized image analysis.
•Design and support technical method validation studies.
•Design, edit, write and review protocols and technical imaging documents (e.g., technical manuals, imaging review charters).
•Work with statisticians on analysis plans involving imaging endpoints.
•Support standardization of imaging methodologies across sites and countries, in order to enable clinical trials leading to dose selection and earlier molecule decision points.
•Engage actively in relevant precompetitive initiatives and consortia.
•Prepare and present documentation of imaging and/or clinical trial results to teams, corporate committees, regulatory agencies, and outside audiences.
•Establish and maintain contacts with external experts and opinion leaders on a regional and international basis.
•Collaborate with external thought leaders and researchers to devise and run collaborative research projects.
•Publish results of research projects and clinical trials as appropriate.
•Support the Lilly brand with planning of symposia/publications/speaking engagements.
•Participate in extramural scientific relations such as pharmaceutical industry associations, and professional scientific organizations on local and international scale
•PhD, and a minimum of 6 years post-graduate experience with a documented strong research background in application of clinical imaging biomarker work.
•At least 2 years experience working in Alzheimer’s research.
•Demonstrated sound understanding of scientific principles, experimental method and study design.
•Demonstrated strong organizational skills.
•Demonstrated excellent written and verbal communication abilities.
•Demonstrated excellent problem-solving abilities through utilization of good judgment and networking skills.
•Demonstrated strong interpersonal and teamwork skills.
•Demonstrated strong self-management skills.
•Publications in peer-reviewed scientific journals
•Experience in the pharmaceutical industry environment
Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status. …
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Source: Nature Jobs