Closing date : 23/08/2015

Reference : M&HS-06850

Faculty / Organisational unit : Medical & Human Sciences 

School / Directorate : Institute of Inflammation and Repair

Division : Centre for Respiratory and Allergy Research

Employment type : Fixed Term

Duration : 3 years

Location : Core Technology Facility

Salary : £30,434 to £31,342 per annum

Hours per week : Full time 

You will join an interdisciplinary team of fungal geneticists and computational scientists and work with several Principle Investigators to ensure timely accomplishment of project-specific goals. This will involve original laboratory based research under the academic supervision of Dr Elaine Bignell , Dr Mike Bromley and Dr Paul Bowyer working to identify the molecular basis of pathogenicity in the mould A. fumigatus.

The aims of the project are to:

• Identify, using in vivo and in vitro infection models and a state-of-the-art parallel fitness profiling assay which uses next generation DNA sequencing, the cohort of A. fumigatus transcription factors required for pathogenesis in the mammalian host and characterise the dominant mechanistic processes driving pathogenicity.
• Define, using ChIP-Seq analysis, and characterise the network of gene promoters bound by these transcription factors  and identify master regulators of A. fumigatus pathogenicity.
• Work with bioinformaticians to integrate transcriptome and ChIP-Seq data, and apply state-of-the-art Bayesian network inference algorithms, to resolve the architecture of the regulatory network directing mould pathogenicity.

The Institute of Inflammation and Repair is committed to promoting equality and diversity, including the Athena SWAN charter for promoting women’s careers in STEMM subjects (science, technology, engineering, mathematics and medicine) in higher education. The Institute received a Bronze Award in 2013 for their commitment to the representation of women in the workplace and we particularly welcome applications from women for this post. Appointment will always be made on merit. For further information, please visit http://www.mhs.manchester.ac.uk/about-us/athena/ .

Enquiries about the vacancy, shortlisting and interviews:

Name: Dr Elaine Bignell

Email: elaine.bignell@manchester.ac.uk

Or

Name: Dr Mike Bromley

Email: Mike.Bromley@manchester.ac.uk

General enquiries:

Email: hrservices@manchester.ac.uk

Tel: 0161 275 4499

Technical support:

Email: universityofmanchester@helpmeapply.co.uk

Tel: 01565 818 234

Date of External posting: 23 July 2015

This vacancy will close for applications at midnight on the closing date.

Further particulars including job description and person specification are available on the University of Manchester website – click on the ‘Apply’ button below to find out more.